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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
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下一代图解合成图像采集优化用于专用PET-DBT减弱校正.

Trevor L Vent1, Bruno Barufaldi1, Raymond J Acciavatti1

  • 1Department of Radiology, University of Pennsylvania, Philadelphia, United States.

Proceedings of SPIE--the International Society for Optical Engineering
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PubMed
概括

以集成正子发射断层扫描 (PET-DBT) 的下一代断层合成 (NGT) 显示了密集组织分类和乳腺细分的改进. 优化的采集几何增强了图像质量,并减少了与传统数字乳腺图片合成相比,体积的高估.

关键词:
减弱纠正的纠正减弱纠正二元分类是二元分类中的一种.数字乳腺图片合成多模式成像技术多模式成像技术定子发射断层扫描 (PET).射线追踪 (ray tracing) 是一种光线追踪技术.灵敏度指数是一个灵敏度指数.虚拟临床试验 虚拟临床试验

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科学领域:

  • 医疗成像医学成像
  • 放射学 放射学是一门学科.
  • 生物医学工程 生物医学工程

背景情况:

  • 数字乳腺图解合成 (DBT) 是乳腺癌检测的关键成像方式.
  • 将正子发射断层扫描 (PET) 与DBT (PET-DBT) 集成,有可能提高诊断准确度.
  • 优化采集几何结构对于提高PET-DBT性能至关重要.

研究的目的:

  • 为了研究为下一代拓合成 (NGT) 原型的定制采集几何.
  • 为了改善乳房内的密度/脂肪组织分类.
  • 为了提高乳房轮细分,以便更好地进行图像分析.

主要方法:

  • 使用OpenVCT虚拟临床试验框架模拟了各种NGT获取几何.
  • 用人类形状的乳房幽灵来进行现实的模拟.
  • 与传统的DBT相比,比较了定制的NGT几何 (40-200毫米PA运动) 和传统的DBT.
  • 使用接收机运行特征 (ROC) 曲线和曲线下的面积 (AUC) 来量化分类性能.
  • 计算的重建乳房体积和敏感度指数 (d).

主要成果:

  • 在NGT中增加前后 (PA) 射线源运动,与传统的DBT相比,减少了乳房体积的高估.
  • 随着PA源运动的增加,AUC和灵敏度指数 (d1) 都增加了.
  • 定制的NGT几何体表现出优越的脂肪腺分类和细分.

结论:

  • 下一代图解合成 (NGT) 采集几何学可以显著改善乳腺组织的分类和细分.
  • 优化的NGT参数提高了PET-DBT应用的图像质量.
  • 这些发现表明,NGT为PET-DBT提供了比传统DBT更好的减弱校正.