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治疗中的跨直流刺激:元分析和系统审查

Yujie Chen¹, Zhujing Ou¹, Nanya Hao¹

¹Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Frontiers in neurology

|November 26, 2024

概括

跨直流刺激 (tDCS) 有效地减少了患者的发作频率短期. 这种非侵入性治疗耐受性很好,但它对认知功能的影响需要进一步研究.

科学领域:

神经学神经学
神经科学是一个神经科学.
医疗器械医疗器械

背景情况:

耐火性是一种重大的临床挑战.
超直流刺激 (tDCS) 是一种新兴的非侵入性神经调节技术.
之前的审查表明tDCS对的潜在疗效,需要强大的元分析.

研究的目的:

进行首次元分析,评估tDCS在治疗中的有效性.
综合来自tDCS随机对照试验 (RCT) 的证据,以减少发作频率.
评估tDCS对认知功能的影响及其安全概况.

主要方法:

在PubMed,Embase,Cochrane图书馆和科学网络中进行全面的文献搜索,截至2024年5月.
包括随机对照试验 (RCT) 评估的tDCS.
使用Cochrane RoB2.0工具进行偏差风险评估;主要结果:发作频率变化和≥50%的发作减少.

主要成果:

14个涉及608项初步研究的RCT被纳入了元分析.
tDCS显著降低了发作的频率 (WMD 0.41,95% CI 0.24,0.59).
亚组分析显示在叶中有效,在较短的治疗持续时间 (<5次) 和早期随访 (2个月内) 中益处更大. 没有注意到显著的认知改善.

结论:

tDCS是一种安全有效的短期辅助疗法,用于减少发作的发作频率.
目前的证据不支持tDCS用于患者的认知增强.
需要进一步的研究来探索tDCS在的长期疗效和认知影响.

关键词:

大脑的两极分化大脑刺激刺激大脑神经刺激神经刺激随机对照试验是随机对照试验.发作发作发作在叶发作.通过骨进行电刺激.

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