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预测ipsilateral 关节上关节淋巴结病理完整反应:基于炎症标志物的诺莫图.

Chen Zhou1,2,3, Xian Wu4, Rongruo Lin1,2

  • 1Division of Breast Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.

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概括

在新辅助化疗 (NAC) 后预测侵袭性平细胞癌 (ISLN) 病理完整反应 (pCR) 是至关重要的. 炎症标志物,瘤标志物和激素受体状态有效预测ISLN pCR并改善生存结果.

关键词:
炎症标志物 炎症标志物双侧上关节性淋巴结 (ISLNs) 是一种淋巴结.新辅助化疗 (NAC) 的使用这个名字是名ogramogram.病理完整反应 (PCR) 的方法预后因素 预后因素

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科学领域:

  • 在瘤学瘤学.
  • 生物标志物 生物标志物
  • 化疗 化疗是一种化学疗法.

背景情况:

  • 使用炎症标志物的新辅助化疗 (NAC) 后侵袭性平细胞癌 (ISLN) 病理完整反应 (pCR) 的预测尚未研究.
  • 这些标记物对ISLN pCR的预后价值在很大程度上仍未得到研究.

研究的目的:

  • 在NAC之后开发和验证ISLN pCR的预测模型.
  • 评估ISLN pCR的预后意义.

主要方法:

  • 在导出队列 (n=120) 中使用逻辑回归构建了一个名图,并在独立队列 (n=45) 中验证.
  • 预测因素包括治疗前的中性粒细胞与淋巴细胞比率 (NLR),激素受体 (HR) 状态,全身免疫炎症指数 (SII),CEA,CA15-3和抗HER2治疗.
  • 使用ROC曲线和AUC值来评估模型的准确性.

主要成果:

  • 诺米图表显示出高预测准确度,AUC值为0.906 (训练),0.888 (测试) 和0.828 (验证).
  • 治疗前的NLR,HR状态,SII,CEA,CA15-3,以及抗HER2疗法是ISLN pCR的显著预测因素.
  • 实现ISLN pCR显著与改善患者预后相关.

结论:

  • 炎症和瘤标志物的组合,以及HR状态和抗HER2治疗,有效地预测ISLN pCR.
  • 在接受NAC的患者中,ISLN pCR是改善生存结果的重要指标.