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在接受皮肤冠状动脉干预的患者中,血的动脉生成指数和重复的目标血管再血管化之间的U形关系:一项回顾性研究

Xingjie Huang¹, Song Wen², Zehan Huang²

¹Department of Cardiology, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.

Frontiers in endocrinology

|November 26, 2024

概括

血的动脉生成指数 (AIP) 显示了在冠状动脉干预后重复目标血管再血管化 (TVR) 的U形联系. 这种风险在女性中更高,这表明AIP是AIP.

科学领域:

心血管医学心血管医学
生物标志物生物标志物
干预心脏病学干预心脏病学

背景情况:

血动脉生成指数 (AIP) 是心脏代谢风险的公认标志物.
它在冠状动脉疾病 (CAD) 的预后价值需要进一步调查.
本研究研究了AIP与皮肤穿刺冠状动脉干预 (PCI) 后不良事件的关联.

研究的目的:

调查AIP与主要心脏和脑血管不良事件 (MACCEs) 之间的关联.
评估AIP在患有CAD的患者中进行PCI的预后相关性,使用药物排泄支架 (DES).
探索AIP-MACCEs协会中的剂量反应关系和子组差异.

主要方法:

对2250名接受DESPCI的患者进行了回顾性队列研究.
主要终点:MACCEs (心肌梗塞,重复TVR,中风,全因死亡率).
使用了后勤回归,受限立方线和子组分析.

主要成果:

在混调整后,AIP (每增加1个SD) 与TVR风险增加有关 (OR=1.26,P=0.042).
在女性中观察到显著的关联 (OR=2.33,P=0.002),但在男性中没有,这表明性别相互作用 (P=0.017).
确定了AIP和TVR之间的U形关系,AIP为0.20的风险增加.

结论:

在患有DES的PCI患者中,AIP与TVR呈现U形关联,特别是在女性中.
这些发现表明,AIP是预测CAD患者DES植入后TVR风险的有价值的血标志物.
对AIP的临床监测可能有助于预防TVR,并改善该患者群体的治疗结果.

关键词:

血的异构指数的血指数.冠状动脉疾病是一种冠状动脉疾病.药物释放的支架可以释放药物.通过皮肤进行冠状动脉干预.目标血管的重血管化

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