周围神经病变对2型糖尿病患者大脑功能的潜在影响
Dongsheng Zhang1, Yang Huang1, Xiaoling Zhang1
1Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
Frontiers in endocrinology
|November 26, 2024
概括
在2型糖尿病 (T2DM) 患者的糖尿病外围神经病变 (DPN) 改变了大脑连接,影响了运动和认知功能. 这些大脑变化可能是DPN发展的基础,影响感觉运动控制.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 医疗成像医学成像
背景情况:
- 在2型糖尿病 (T2DM) 中,糖尿病外围神经病变 (DPN) 和大脑功能障碍之间的联系机制尚未完全理解.
- 下肢感觉运动皮质 (LSM) 的休息状态功能连接 (FC) 提供了一种间接方法来评估DPN对大脑的影响.
研究的目的:
- 为了调查T2DM患者的脑功能连接的变化与没有DPN.
- 描述DPN对LSM静止状态FC的影响.
- 探索FC异常与临床/认知措施之间的相关性.
主要方法:
- 招募了三组:具有DPN的T2DM (n=44),没有DPN的T2DM (n=39) 和健康的对照组 (HCs,n=43).
- 利用静止状态功能磁共振成像 (rs-fMRI) 来分析整个大脑的LSM FC.
- 进行神经心理评估以评估认知功能.
主要成果:
- 与HC相比,ND组的LSM FC与右侧角皮质 (LOTC) 和中部上额回 (SFGmed) 发生了变化.
- DPN组表现出与小脑叶VI,LOTC,面额前额皮质 (rPFC) 和前带带状回形 (ACC) 相比HCs的LSM FC减少.
- 与ND组相比,DPN组显示LSM FC与ACC,SFGmed和rPFC的减少.
结论:
- 在DPN发作之前,T2DM患者可能会出现与运动相关的视觉知觉受损.
- DPN显著影响参与运动控制和功能的大脑区域,超出了运动缺陷.
- 在DPN中改变的大脑连接可能代表一个核心的神经病理机制.
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