神经退行性疾病和肠道-微生物组-大脑轴:文学综述
Bindu Jyothi Dandamudi1, Kathrina Antheia M Dimaano2, Nensi Shah1
1Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus
|November 26, 2024
概括
肠道微生物群影响大脑健康和神经退行性疾病. 肠道功能障碍与这些疾病有关,但针对微生物组的疗法对治疗有希望.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 神经退行性疾病是复杂的,与年龄相关的疾病,患病率高.
- 肠道微生物组显著影响人类健康,产生神经活性化合物.
- 肠道-微生物组-大脑轴是一个双向通信通道,影响大脑功能.
研究的目的:
- 审查当前对肠道微生物组在神经退行性疾病中的作用的理解.
- 探索将肠道失调与神经退行症联系起来的潜在机制.
- 检查针对神经退行性疾病的肠道微生物群的治疗策略.
主要方法:
- 在五个电子数据库 (PubMed,Scopus,Ovid Medline,Cochrane Review,Google Scholar) 中进行了全面的文献搜索.
- 包括英语语言的研究从开始到2024年6月.
- 关键词:肠-大脑轴,微生物组失调,神经退行,阿尔茨海默病,帕金森病,肠道微生物组.
主要成果:
- 肠道功能失调与通过免疫调节,增加血脑屏障透性和神经毒性代谢物产生的神经退行性疾病的发病有关.
- 诸如益生菌,益生菌和便微生物群移植等治疗干预措施在控制神经退行症方面显示出潜力.
- 肠道-微生物组-大脑轴为新疗法开发提供了一个有前途的途径.
结论:
- 肠道微生物组的改变与神经退行性疾病的发展和进展有关.
- 针对肠道微生物组提供了一种潜在的策略,以恢复微生物平衡并减缓疾病的进展.
- 进一步的研究对于验证基于微生物组的疗法在神经退行性疾病中的临床应用至关重要.
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