在健康衰老和多种神经疾病中估计的大脑年龄
Li Chai1, Jun Sun1, Zhizheng Zhuo1
1Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Journal of magnetic resonance imaging : JMRI
|November 26, 2024
概括
通过大脑年龄差评估的大脑衰老,揭示了在MS,AD和PD等神经系统疾病中加速衰老. 这个大脑年龄差距与大脑缩,白质病变和认知衰退有关.
科学领域:
- 神经成像是一种神经成像.
- 人工智能在医学中的应用
- 老年学是一门学科.
背景情况:
- 在一般人群中,大脑衰老机制和神经系统疾病仍然不清楚.
- 了解大脑衰老对于诊断和管理神经疾病至关重要.
- 加速的大脑衰老可能表明潜在的病理过程.
研究的目的:
- 在健康个体和患有神经系统疾病的患者中描述大脑衰老模式.
- 研究大脑衰老指标的临床相关性.
- 在各种神经疾病中确定大脑年龄差距 (BAG) 的差异.
主要方法:
- 从2913名健康对照和患有MS,NMOSD,AD,PD和cSVD的患者的3DT1加权MRI扫描进行了回顾性分析.
- 利用3D卷积神经网络模型来估计大脑年龄.
- 计算了大脑年龄差距 (BAG),并将其与MRI指标,认知和物理指标相关联.
主要成果:
- 脑年龄加速 (BAG ≥5年) 的健康个体显示白质强度增加 (WMH) 和区域大脑体积减少.
- 与健康对照人群相比,在MS,NMOSD,AD,PD和cSVD中观察到明显更高的BAG.
- 增加的BAG与MS中大脑缩,WMH负担,认知障碍和身体残疾相关.
结论:
- 在健康个体中,加速的大脑衰老与WMH和区域大脑体积损失有关.
- 神经系统疾病表现出明显的加速大脑衰老模式.
- 加快的大脑衰老在临床上是相关的,与认知和身体功能障碍相关.
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