在favipiravir治疗期间母乳养的安全性:一个案例研究
Yuka Sano Wada1, Jumpei Saito2, Wakako Yamamoto3
1Division of Neonatology, Center for Maternal-Fetal, Neonatal, and Reproductive Medicine, National Center for Child Health and Development, Japan.
概括
费维皮拉维尔转移到母乳是显著的,但可以最小化. 哺乳是安全的,如果时间正确,避免药物度高峰后药物治疗.
科学领域:
- 药理学 药理学是指药理学的学科.
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 传染性疾病 传染性疾病
背景情况:
- 法维皮拉维尔是一种在COVID-19大流行期间使用的抗流感药物.
- 关于高剂量的法维皮拉维尔转移到母乳中的数据有限.
- 一名COVID-19患者提供了牛奶和血液样本,以评估药物转移.
研究的目的:
- 为了量化人乳和母亲血液中的favipiravir度.
- 通过母乳养来确定favipiravir的相对婴儿剂量.
- 为提供关于在法维皮拉维尔治疗期间母乳养安全的指导.
主要方法:
- 采集并分析了母体血液和母乳样本,以检测法维皮拉维尔度.
- 药物度被测量在不同的时间点相对于药物管理.
- 婴儿的相对剂量是根据测量的牛奶度来计算的.
主要成果:
- 牛奶中的法维皮拉维尔度在3.0-80.9微克/毫升之间,血液中的度在3.5-78.4微克/毫升之间.
- 乳中的favipiravir度峰值发生在剂量后1.3小时,达到80.9微克/毫升.
- 计算出的婴儿相对剂量为15.2%.
结论:
- 在法维皮拉维尔治疗期间,母乳养并非禁忌.
- 在药物注射前立即进行母乳养的时间将使婴儿暴露最小化.
- 建议在药物度达到峰值后 (1.3小时后) 避免母乳养.
关键词:
在 COVID-19 疫情中,母乳养 哺乳期 母乳养一个案例研究研究.这就是为什么favipiravir.人类母乳是人类的母乳.婴儿婴儿婴儿婴儿婴儿婴儿婴儿牛奶与血中的药物度比率.母乳是母亲的牛奶.相对婴儿剂量相对婴儿剂量.更多相关视频
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