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基于UPLC-Q-Orbitrap-MS的新化合物囊中的化学成分的快速识别

Siyue Chen¹, Yajie Dou¹, Shumin Zhang¹

¹School of Chinese Material Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Rapid communications in mass spectrometry : RCM

|November 26, 2024

概括

使用UPLC-Q-Orbitrap-MS的新方法在新化合物囊 (NCAC) 中确定了56种化合物. 这一全面的分析有助于理解NCAC.

科学领域:

植物化学植物化学
分析化学分析化学
药理学是指药理学,它是指药理学.

背景情况:

新化合物囊 (NCAC) 的化学成分仍然不完全理解.
这种知识差距阻碍了药理学研究和合理的药物使用.
需要一个全面的分析方法来阐明NCAC的组成部分.

研究的目的:

建立一种快速而敏感的方法,以全面分析NCAC中的成分.
确定NCAC中存在的主要化学化合物.
为改善NCAC质量控制标准提供基础.

主要方法:

采用超高性能液态染色学与四极轨道式质谱学 (UPLC-Q-Orbitrap-MS) 结合使用.
使用UPLC分离提取组件,并在正离子和负离子模式下获得碎片信息.
将保留时间和质谱数据与用于化合物识别的文献进行比较.

主要成果:

在NCAC中成功识别了56种化合物.
检测到的化合物包括21个染色体,6个pyranones,7个anthraquinones,7个anthrones,5个类化合物和4个氨基酸.
该分析为NCAC提供了详细的组成信息.

结论:

开发的UPLC-Q-Orbitrap-MS方法有效地识别了NCAC的主要成分.
这种分析方法将大大有助于提高NCAC的质量控制标准.
综合成分分析对于NCAC的科学验证和应用至关重要.

关键词:

清代清代清代是一个在 UPLC-Q-Orbitrap-MS 中.是一种.碎片化路径的碎片化路径新的化合物囊囊

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