相关实验视频

Updated: Jun 6, 2025

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy
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High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy

Published on: February 7, 2019

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基于对联动因子分析的共局部转录因子的识别

Li Liu1, Lu Han1,2, Kaiyuan Han3

  • 1Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, Quzhou, China.

IET systems biology
|November 26, 2024
PubMed
概括

研究人员确定了人类基因组中的转录因子 (TF) 结合模式. 他们发现,来自同一家族的TFs经常相互竞争,而另一些则相互合作,其中一些模式因细胞类型而异.

关键词:
它们是DNA DNA DNA DNA.生物信息学是一种生物信息学.数据挖掘是数据挖掘的一个方法.基因组学就是基因组学.统计分析是一种统计分析.

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Transcription Factors02:16

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Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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