Joaquín González Aroca1

  • 1Faculty of Sciences, Universidad de La Serena, Chile.

概括

门德尔随机化 (MR) 使用遗传变异进行强有力的因果推断,超过传统的观察性研究. 了解其核心假设 - - 相关性,独立性和排除限制 - - 是有效地利用流行病学中的MR的关键.

相关概念视频

Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
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Law of Independent Assortment02:03

Law of Independent Assortment

While Mendel’s Law of Segregation states that the two alleles for one gene are separated into different gametes, a different question of how different genes are inherited remains. For example, is the gene for tall plants inherited with the gene for green peas? Mendel asked this question by experimenting with a dihybrid cross; a cross in which both parents are homozygous for two distinct traits resulting in an F1 generation that are heterozygous for both traits.
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Dihybrid Crosses01:18

Dihybrid Crosses

Overview
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Monohybrid Crosses01:20

Monohybrid Crosses

Overview
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