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Updated: Jun 6, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Setdb1损失诱导I型干扰素和黑色素瘤的免疫清除

Meaghan K McGeary1, William Damsky1,2, Andrew J Daniels3

  • 1Department of Pathology, Yale University, New Haven, Connecticut.

Cancer immunology research
|November 26, 2024
PubMed
概括

黑色素瘤中Setdb1的损失通过激活内源逆转录病毒 (ERV) 并触发I型干扰素信号,从而提高瘤免疫力,从而导致CD8+ T细胞介导的瘤清除. 这突出了ERV和干扰素调节器作为潜在的癌症治疗点.

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