不心脏病的短期抗生素治疗与标准持续时间抗生素治疗:多中心回顾性队列研究
Nofar Hezkelo Attias1, Tal Schlaeffer-Yosef2,3, Itay Zahavi4
1Internal Medicine F, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel.
Infection
|November 26, 2024
概括
较短的无心脏病治疗对于某些患者是有效和安全的. 持续时间没有影响死亡率或复发率,这表明可以考虑更短的疗程.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 无心脏病治疗指南建议在没有强有力的证据的情况下长期治疗.
- 临床医生经常根据临床判断使用更短的治疗时间.
- 评估短期无心脏病治疗的有效性至关重要.
研究的目的:
- 评估非心脏病治疗时间缩短的疗程的有效性和安全性.
- 为了确定患者的特征和与成功的短期治疗相关的疾病因素.
- 为了比较不同治疗持续时间的结果,包括死亡率和复发率.
主要方法:
- 在176名被诊断患有无心脏病的患者中进行的多中心回顾性队列研究 (2007-2022年).
- 幸存90天的患者被分为短期 (≤90天),中期 (91-180天) 和长期 (>180天) 治疗组.
- 基线特征,疾病表现,一年死亡率,复发率和不良事件的比较.
主要成果:
- 治疗持续时间与一年内全因死亡率 (p=0.945) 或疾病复发 (p=0.509) 无关.
- 在73名患有孤独性肺性心脏病的患者中,较短的治疗 (≤90天) 在免疫功能低下的个体中没有复发,死亡率低 (10%).
- 在所有治疗持续时间组中,不良事件发生率相似.
结论:
- 无心脏病可以安全地治疗,持续时间比传统上建议的要短得多.
- 临床指导,个别病例患者选择是成功短期治疗的关键.
- 证据支持针对非心脏病的个性化治疗量身定制.
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