使用肠肝芯片揭示聚乙烯微塑料的运输,吸收和损坏
Yushen Wang1,2, Junlei Han1,2, Wenteng Tang1,2
1School of Mechanical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China. liwang@qlu.edu.cn.
Lab on a chip
|November 26, 2024
概括
这项研究引入了一种肠肝芯片模型,用于跟踪消化系统和肝脏中的微塑料 (MP). 增加的肠周平静可减少MP的运输和肝脏损伤,突出显示其保护作用.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 生物医学工程 生物医学工程
背景情况:
- 微塑料 (MP) 是广泛存在的环境污染物.
- MPs可以进入人体肠道,并在肝脏中积累.
- 目前的平台缺乏研究MP运输和肠肝轴上的损伤的能力.
研究的目的:
- 开发一种新的肠肝芯片 (GLOC) 模型.
- 研究MPs在肠肝轴上的转移和积累.
- 为了探索肠周心的保护作用,防止MP诱导的肝损伤.
主要方法:
- 开发了一个具有生物模拟肠周立体和肝流的GLOC.
- 模仿了肠道 (屏障功能) 和肝脏 (代谢) 的生理特征.
- 将聚乙烯MPs (100nm) 输入到芯片中,以不同度和周围静电水平.
主要成果:
- 增加的肠周立体会降低MP的传输速率.
- 更高的环静止与氧化应激降低和肝细胞损伤相关.
- GLOC有效地模拟了MP的运输和肝脏积累.
结论:
- 该GLOC平台提供了洞察力MP行为在肠肝轴.
- 肠周平静在缓解MP诱导的肝损伤方面发挥着至关重要的作用.
- 该模型为评估器官特异性MP毒性提供了一个新的工具.
相关概念视频
Types of Step-Growth Polymers: Polyesters
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Plastic Behavior
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and reloaded.
Plasticizers
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Biodeterioration
Biodeterioration refers to the unwanted alteration of materials caused by microorganisms—especially fungi—which damage both organic substrates (paper, wood, textiles) and inorganic ones (stone, plaster, glass). Unlike abiotic decay, biodeterioration results from biological activity that produces physical disruption and chemical degradation.Physical deterioration occurs as fungal hyphae penetrate pores, cracks, and surface irregularities. Hyphal turgor pressure, thigmotropic growth along...
Bioplastics
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
Microbial Bioremediation of Plastics
Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...


