关于皮肤癌预防方法和固体器官移植受体查方案的最新情况:范围审查
Pamela Korzeniowski1, Cynthia Griffith2, Peter A Young3
1Department of Dermatology, Veterans Administration of North Texas, Fort Worth, TX, USA. pbaxterj@gmail.com.
Archives of dermatological research
|November 26, 2024
概括
固体器官移植接受者面临高皮肤癌风险. 本综述总结了关于预防和查的证据,强调了风险分层的SUNTRAC工具以及对标准化指南的需求.
科学领域:
- 皮肤病学 皮肤病学
- 移植医学 移植医学 移植医学
- 在瘤学瘤学.
背景情况:
- 固体器官移植接受者 (SOTRs) 由于长期免疫抑制,皮肤癌的风险明显增加.
- 目前美国关于皮肤癌风险分层和SOTR查的指导方针没有标准化,造成了关键的知识差距.
研究的目的:
- 进行范围审查,总结有关皮肤癌预防现有证据和SOTRs查协议的现有证据.
- 为制定标准化临床指导方针提供信息,以管理这种脆弱人群中的皮肤癌风险.
主要方法:
- 在OVID,MEDLINE和CINAHL Plus数据库的系统文献搜索 (2019年1月 - 2023年2月).
- 包括英语研究的风险分层,查和预防疗法在成人SOTRs.
- 使用JBI PRISMA和推分类学 (SORT) 的数据提取和质量分级.
主要成果:
- 审查了36篇文章,重点是查方案 (36%) 和化疗预防 (31%).
- 确定SUNTRAC工具 (2019) 是一个经过验证的风险分层模型.
- 有效的预防策略包括全身 (阿西特雷丁,卡佩西塔,尼亚辛胺) 和局部 (5-甲,光动力学疗法) 治疗,并总结了证据的强度.
结论:
- 对于SOTRs,有必要制定标准化皮肤癌查和预防指南.
- SUNTRAC工具为风险分层提供了坚实的基础,需要在不同人群中进行验证.
- 未来的研究应该优先考虑验证SUNTRAC,进行局部化疗预防的RCT,并改善患者教育,特别是对于皮肤有色患者.
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