调节细胞在乳腺癌中的复杂作用:对免疫病原发生和免疫疗法的影响
1Department of Oncology, Yantaishan Hospital Affiliated to Binzhou Medical University, Shandong Province, Yantai City, People's Republic of China.
Breast cancer (Tokyo, Japan)
|November 26, 2024
概括
乳腺癌在一个免疫抑制的微环境中壮成长. 本综述详细介绍了免疫抑制细胞 (如Bregs,Tregs,TAMs,TANs,MDSCs) 和它们的作用,为乳腺癌的向免疫疗法提供了洞察力.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 乳腺癌 (BCs) 通常与免疫抑制性瘤微环境有关,使免疫规避成为可能.
- 关键的免疫抑制细胞包括调控性B细胞 (Bregs),调控性T细胞 (Tregs),与瘤相关的巨细胞 (TAMs),与瘤相关的中性粒细胞 (TANs) 和髓质衍生抑制细胞 (MDSCs).
- 瘤进展和免疫逃避进一步由细胞因子和由瘤和免疫抑制细胞释放的因素促进.
研究的目的:
- 审查乳腺癌瘤微环境中的免疫抑制细胞的特征和作用.
- 探索潜在的治疗策略,以这些调节细胞为瘤抗作用的目标.
- 讨论乳腺癌免疫治疗的挑战和现状.
主要方法:
- 这项研究是对现有文献的全面审查.
- 它合成了关于乳腺癌中各种免疫抑制细胞种群的生物学和功能的信息.
- 该审查分析了针对这些细胞的当前和潜在的治疗干预措施.
主要成果:
- 免疫抑制细胞是促进瘤免疫逃避和乳腺癌进展的关键参与者.
- 这些细胞的治疗向 (消除,无活化,重编程) 已显示出有希望的抗瘤反应.
- 由于这些细胞的异质性,适应性和动态性,存在重大挑战,影响其作为生物标志物和治疗点的使用.
结论:
- 了解免疫抑制细胞的多面性作用对于推进乳腺癌免疫治疗至关重要.
- 开发向疗法需要解决这些细胞的复杂性和适应性.
- 乳腺癌的免疫疗法,特别是向瘤微环境,是一个具有重大潜力的不断发展的领域.
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