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线粒体miRNAs和纤维肌痛:新的生物标志物候选者

Khayala Rasulova1, Banu Dilek2, Deniz Evrim Kavak1,3

  • 1Department of Medical Biology and Genetics, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey.

Molecular biology reports
|November 26, 2024
PubMed
概括

纤维肌痛综合征 (FMS) 患者在外周血液单核细胞 (PBMC) 中表现出线粒体微RNA-145-5p (mitomiR-145-5p) 的水平升高. 这一发现表明mitomiR-145-5p可能在FMS病理学中发挥作用,并为该病症提供了新的视角.

关键词:
纤维肌痛是一种纤维肌痛.微RNA (miRNA) 是一种微型RNA.线粒体中的线粒体.线粒体相关的miRNA (mitomiR)

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...