代谢功能障碍相关的脂肪性肝病与甲状腺癌风险之间的关联:系统性审查和元分析
JiaHao Chen1, YingZheng Gao, Tao Fu
1The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang Province, China.
European journal of gastroenterology & hepatology
|November 26, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与甲状腺癌的更高风险有关. 这一对八项队列研究的分析证实了这一关联,强调了中国人群和超重个体的风险增加.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越多地因其对全身健康的影响而得到认可.
- 现有的研究表明,MASLD与各种癌症之间存在联系,但关于甲状腺癌风险的证据有限且不一致.
研究的目的:
- 对队列研究进行全面的分析,以澄清MASLD与患甲状腺癌的风险之间的关联.
- 为临床和公共卫生考虑提供关于MASLD-甲状腺癌联系的强有力的证据.
主要方法:
- 在主要数据库 (Web of Science,Embase,Cochrane Library,PubMed) 进行系统的文献搜索,截至2024年9月24日.
- 使用R软件 (版本4.4.1) 对八项队列研究 (n=18,925,396名参与者) 的元分析.
- 随机效应模型由于中等异质性 (I2 > 50%) 适用于聚合风险估计.
主要成果:
- MASLD与甲状腺癌的风险增加显著相关 (HR=1.46;95% CI:1.14-1.86).
- 亚组分析表明,在中国人口 (HR=2.24) 和超重个体 (HR=1.29) 中,相关性更强.
- 在这种关联中没有观察到基于性别的显著差异.
结论:
- 这一元分析提供了强有力的证据,表明MASLD是甲状腺癌的独立风险因素.
- 这些发现强调了在甲状腺癌风险评估和预防策略的背景下考虑肝脏健康的重要性.
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