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Updated: Jun 6, 2025

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

循环RNA作为生命活动的多面分子调节剂和衰老的潜在生物标志物

Anna-Maria D Zharova¹, Alexey D Perenkov¹, Maria V Vedunova^1,2

¹Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.

|November 26, 2024

概括

循环RNAs (circRNAs) 由于其稳定性和与年龄相关的积累,显示出作为衰老生物标志物的潜力. 这些分子可能推动衰老过程,并为与年龄相关的疾病提供治疗点.

科学领域:

老年学是一门学科.
分子生物学分子生物学
生物化学生物化学

背景情况:

老龄化是医疗保健系统面临的主要挑战,需要可靠的生物标志物来评估其进展.
循环RNAs (circRNAs) 是稳定的,在生物流体中发现的年龄积累分子,使它们成为有希望的衰老生物标志物.
了解circRNA生物发生和功能对于衰老研究至关重要.

研究的目的:

审查当前关于circRNA表达和衰老中的功能知识.
探索circRNAs在衰老特征中的作用,例如基因组稳定性和新陈代谢.
确定circRNAs作为潜在的表观遗传生物标记物和与年龄有关的疾病的治疗点.

主要方法:

对科学数据库的系统审查,以寻找老化中的circRNA表达数据.
对circRNA生物发生和调节机制的分析.
专注于参与与衰老相关的细胞过程的circRNAs.

主要成果:

循环RNA随着年龄的增长而积累,并且在包括人类在内的物种中以不同的方式表达.
与年龄相关的circRNA积累和放松调节可能会推动衰老过程.
特定的circRNAs (例如circFOXO3,circRNA100783,circPVT1) 与衰老有关.

结论:

循环RNAs代表了一类新的表观遗传生物标志物,用于衰老.
循环RNAs可能在衰老和相关疾病中发挥起因作用.
向circRNAs可能为与年龄相关的疾病提供新的治疗策略.

关键词:

老化的老化衰老的老化生物标志物生物标志物环RNA 环RNA 是一个环RNA.老年人是人口中的老年人.寿命长度寿命长度这是一个ncRNARNA.拼接拼接拼接拼接

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