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Updated: Jun 6, 2025

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining
13:22

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Published on: January 23, 2014

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HUSH表观遗传抑制器复合体使PML核体关联的HSV-1静止基因组沉默

Simon Roubille1, Tristan Escure1, Franceline Juillard1,2

  • 1Université Claude Bernard Lyon 1, Centre national de la recherche scientifique (CNRS) UMR 5261, Institut national de la santé et de la recherche médicale (Inserm) U1315, Laboratoire d'Excellence (LabEx) DEV2CAN, Institut NeuroMyoGène-Pathophysiology and Genetics of Neuron and Muscle (INMG-PGNM), team "Chromatin dynamics, Nuclear Domains, Virus", Lyon 69008, France.

Proceedings of the National Academy of Sciences of the United States of America
|November 26, 2024
PubMed
概括

这种HUSH-SETDB1-MORC2复合体通过用H3K9me3.3标记病毒DNA来抑制单纯疹病毒1 (HSV-1). 病毒蛋白ICP0降解MORC2,重新激活沉默的HSV-1,这表明新的治疗点.

关键词:
胡什 (Hush) 是一种汉语.微生物学 微生物学表观遗传学是指表观遗传学.

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