ZFP36 调节血管光滑肌收缩并维持血压
Xiuru Cui1,2, Yawei Wang1, Hanlin Lu1
1State Key Laboratory for Innovation and Transformation of Luobing Theory, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, 250012, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|November 26, 2024
概括
指蛋白36 (ZFP36) 在高血压中升高. 在血管光滑肌细胞中抑制ZFP36通过调节RGS2降低血压,提供潜在的高血压治疗.
科学领域:
- 心血管生物学 心血管生物学
- 分子医学是分子医学.
- 高血压研究 高血压研究
背景情况:
- 高血压是心血管疾病的主要危险因素,其机制尚不清楚.
- 指蛋白36 (ZFP36) 是一种影响mRNA稳定的RNA结合蛋白.
- 在高血压患者和动物的动脉中,ZFP36的表达升高.
研究的目的:
- 研究ZFP36在高血压中的作用.
- 阐明ZFP36影响血压调节的分子机制.
主要方法:
- 在高血压患者和动物中研究了ZFP36的表达.
- 使用培养的血管光滑肌细胞 (VSMC) 和血管素II (AngII) 刺激.
- 在小鼠和老鼠模型中使用了VSMC特定的ZFP36删除和AAV介导的ZFP36敲除.
- 评估了血管收缩性,血压,细胞内水平和RGS2 mRNA稳定性.
主要成果:
- 在高血压动脉中,ZFP36的表达显著升高.
- 血管素II通过PARP1激活刺激VSMC中的ZFP36表达.
- 在小鼠中,VSMC特有的ZFP36删除降低了血压和血管收缩性.
- ZFP36损害了RGS2mRNA的稳定性,影响了信号传递.
- ZFP36缺乏减轻了AngII诱导的高血压和血管重塑.
- 在大鼠中,ZFP36敲击改善了自发高血压.
结论:
- ZFP36在调节血管光滑肌收缩和血压方面发挥着至关重要的作用.
- ZFP36通过影响RGS2表达和信号来调节血压.
- 抑制ZFP36为高血压治疗提供了一个有前途的治疗策略.
相关概念视频
Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
Autoregulation of Blood Flow
2.2K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
2.2K
Hypertension and Regulation of Blood Pressure
1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
Vascular Spasm
1.2K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
1.2K
Neural Regulation of Blood Pressure
2.7K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
2.7K
Hormonal Regulation of Blood Pressure
2.5K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.5K


