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通过使用子脱脂牛奶作为生物医学应用的培养介质进行生物合成的细菌纤维素-丝水凝

Junchanok Chaikhunsaeng¹, Phasuwit P Phatchayawat², Suchata Kirdponpattara³

¹Bio-Circular-Green-Economy Technology & Engineering Center, BCGeTEC, Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand.

Gels (Basel, Switzerland)

|November 26, 2024

概括

新的丝和细菌纤维素水凝膜是使用子和丝工业的废物制成的. 这些生物相容的薄膜在伤口愈合和组织工程应用方面表现有前途.

科学领域:

生物材料科学生物材料科学
生物技术是生物技术.
材料工程材料工程材料工程

背景情况:

细菌纤维素 (BC) 和丝 (S) 是具有再生医学潜力的生物相容材料.
利用子和丝行业的副产品为生物材料开发提供了一种可持续的方法.

研究的目的:

使用经济有效的方法制造新的丝/细菌纤维素 (S/BC) 水凝膜.
评估这些S/BC膜在伤口愈合和组织工程中的性能和潜在应用.

主要方法:

在子脱脂牛奶/成熟子水培养基中使用*Acetobacter xylinum*生物合成BC.
用粉末薄丝子 (SC) 补充培养基.
由此产生的S/BC水凝膜的机械性能,吸水性和生物相容性的表征.

主要成果:

通过将丝完善地集成到BC矩阵中,S/BC片成功地制造出来.
与成熟的子水 (S/BCW) 相比,从子脱脂牛奶 (S/BCM) 获得的薄膜具有更高的弹性和抗拉强度.
所有的S/BC膜都显示出高吸水率 (400-500%) 和显著改善的细胞粘附,增殖和相互作用.

结论:

S/BC 水凝膜具有出色的生物相容性,机械性能和吸水能力.
使用子脱脂牛奶和丝副产品为创建先进生物材料提供了可持续和有效的途径.
这些S/BC水凝膜是先进的伤口带和组织工程支架的有希望的候选人.

关键词:

细菌纤维素的细菌纤维素.生物聚合物生物聚合物子脱脂牛奶是什么意思这是丝丝.组织工程是组织工程.伤口上使用了伤口护.

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