在未受影响的韩国BRCA1/2突变载体中,风险降低策略的模式分析
Dabin Kim1, Jai Min Ryu2, Sang-Ah Han3
1Department of Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon 14584, Republic of Korea.
Current oncology (Toronto, Ont.)
|November 26, 2024
概括
具有BRCA1/2突变的未受影响个体具有患乳腺癌和卵巢癌的高风险. 在这个韩国队列中,监测和降低风险的干预措施显著较低,需要改善癌症预防策略.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 预防医学 预防医学
背景情况:
- 具有BRCA1/2突变的个体面临着显著增加的乳腺癌和卵巢癌的终身风险.
- 早期检测和预防策略对于BRCA1/2突变携带者至关重要,但对干预吸收的数据有限.
研究的目的:
- 调查癌症监测和降低风险干预措施在不受影响的韩国携带BRCA1/2突变者中的模式.
主要方法:
- 从韩国遗传性乳腺癌 (KOHBRA) 研究中确定了一组未受影响的BRCA1/2突变携带者.
- 一项电话调查评估了癌症发病率,监测模式 (乳腺,卵巢,前列腺),化疗预防,降低风险的手术和动机.
主要成果:
- 在46名参与者中 (15名男性,31名女性),平均随访时间为103个月,10人患有乳腺癌,1人患有卵巢癌,3人患有其他癌症.
- 只有19.4%的人遵守推的乳腺癌监测;卵巢和前列腺监测是不存在的.
- 有9.7%的参与者使用化疗预防,只有1名参与者使用降低风险的salpingo-oophorectomy.
结论:
- 没有受到影响的韩国BRCA1/2突变携带者表现出推的癌症监测,化疗预防和降低风险的手术的低率.
- 迫切需要加强战略,促进高风险人群积极参与降低风险的措施.
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