对于L型肉 Sarcoma的trabectedin:一个回顾性的多中心研究
Sercan Ön1, Barış Köksal2, Zafer Arık2
1Department of Medical Oncology, Tepecik Training and Research Hospital, 35180 Izmir, Türkiye.
Current oncology (Toronto, Ont.)
|November 26, 2024
概括
特拉贝克泰丁在转移性L型瘤中是有效的,这种瘤是在安赛克林后出现的. 局部治疗和客观反应与更好的结果相关,而剂量减少不会使这些罕见癌症的存活率恶化.
科学领域:
- 医学瘤学 医学瘤学
- 肉瘤研究研究 肉瘤研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 转移性L型肉瘤 (脂肉瘤,乳腺肉瘤) 是罕见的,预后不佳.
- 特拉贝克丁是继安赛克林治疗后的一种已知治疗选择.
研究的目的:
- 评估特拉贝克丁在转移性L型肉瘤中的实际有效性和安全性.
- 确定影响治疗结果的预后因素.
主要方法:
- 对98名用trabectedin.in治疗的患者进行了回顾性多中心研究.
- 评估客观反应率 (ORR),疾病控制率 (DCR),治疗失败的时间 (TTF) 和整体存活率 (OS).
- 考克斯回归分析用于预后因素识别.
主要成果:
- ORR为16%,DCR为42%,TTF中位数为3个月,OS中位数为10个月.
- 局部治疗和客观反应与更长的TTF有关.
- 客观反应是OS的积极预后因素;肝转移表明预后不佳.
结论:
- 特拉贝克丁是一种可行的治疗方法,用于L型肉 Sarcoma post-anthracyclines.
- 降低剂量并没有对存活率产生负面影响.
- 将特拉贝克丁与局部疗法结合使用可能会提高疗效.
关键词:
毒性毒性毒性毒性毒性毒性毒性毒性毒性毒性毒埃克泰纳斯基丁 743 种莱奥米奥萨科马斯 (leiomyosarcomas) 是一种癌症.脂质沙尔科马 (liposarcomas) 是一种有针对性的放射治疗.在trabectedin中进行了追踪更多相关视频
08:59Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
Published on: December 11, 2017
7.2K
07:31A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
Published on: May 3, 2021
3.6K
相关概念视频
02:57Targeted Cancer Therapies
7.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.0K
02:56Treatment Resistant Cancers
2.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
2.6K