时间到下一次治疗后的时间,在小细胞肺癌的低进展性非小细胞肺癌中进行定向辐射疗法
Riccardo Ray Colciago1, Chiara Chissotti1,2, Federica Ferrario1,2
1Medicine and Surgery Department, University of Milan Bicocca, 20126 Milano, Italy.
Current oncology (Toronto, Ont.)
|November 26, 2024
概括
进展导向放射治疗 (PDRT) 有效地延迟了对有限的,进展的非小细胞肺癌 (NSCLC) 患者进一步系统治疗的需要. 这种安全和可行的选择为部分患者提供了显著的好处,特别是当早期启动时.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 寡进性非小细胞肺癌 (NSCLC) 在系统治疗后管理有限的疾病进展是一个挑战.
- 进展导向放射治疗 (PDRT) 是一种新兴的策略,用于控制局部疾病的生长.
研究的目的:
- 评估PDRT是否可以延长在患有寡进的NSCLC患者中开始随后的全身治疗的时间.
- 确定影响PDRT后到下一次治疗的时间 (TTNT) 的因素.
主要方法:
- 追溯分析40名患有额外骨寡头进展的NSCLC患者,接受PDRT治疗.
- 寡进的定义是,根据RECIST 1.1/PERCIST 1.0标准,最多有五种进展的病变.
- 用于确定TTNT的主要终点的Cox比例危险回归.
主要成果:
- 在80%的患者中,PDRT延迟了进一步的全身治疗.
- 中位数的TTNT在8个月后还没有达到,Kaplan-Meier的一年估计为81.4%.
- 没有观察到超过3级的不良事件;PDRT是安全的.
结论:
- PDRT是一种有效,安全和可行的治疗寡进性NSCLC的方法.
- 在患有低疾病体积和非转移性寡头进展的患者中,早期PDRT可能会带来实质性的益处.
- 接受≥3线治疗或目标体积较大的患者没有从PDRT中显著受益.
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