围产期炎症导致性取决于性别的心脏功能障碍
Leeann R Pavlek1,2, Kathryn M Heyob1, Nitya R Jacob1
1Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, USA.
Journal of cardiovascular development and disease
|November 26, 2024
概括
早期的炎症和氧气暴露会改变心脏蛋白质,导致成年小鼠的心脏功能障碍. 这些变化,特别是在男性中,表明人类婴儿心脏病风险的潜在预测因素.
科学领域:
- 心血管生物学 心血管生物学
- 新生儿生理学 新生儿生理学
- 健康和疾病的发育起源
背景情况:
- 过早分娩和胎儿生长限制与成人心力衰竭有关.
- 不利的母亲环境有助于胎儿发育不良和早产.
- 新生儿高氧症通常需要为早产婴儿与不成熟的肺部.
研究的目的:
- 测试早期心脏结构蛋白质变化是否预测成人心脏功能障碍.
- 研究心脏适应早期侮辱的性别依赖差异.
主要方法:
- 利用母体炎症 (脂多糖) 和新生儿高氧症的小鼠模型.
- 评估心脏结构蛋白 (阿尔法-肌酶重链) 和左心室功能.
- 在10个月大时检查性别特异性病理变化.
主要成果:
- 雌性小鼠在炎症后的α-肌肉素重链 (αMHC) 表达中出现过渡性下降.
- 暴露于炎症和高氧的雄性小鼠表现出αMHC的延迟但显著增加.
- 左心室功能与蛋白质变化相关,男性表现出更严重的心脏表型.
结论:
- 早期心脏收缩蛋白质的改变暂时与心脏功能障碍有关.
- 雄性小鼠表现出更严重的性别依赖心脏适应.
- 这些发现表明,在生长受限制的人类婴儿中,对心脏病风险的潜在预测价值.
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