切换/非发酵糖 (SWI/SNF) 鼻状细胞癌的复杂部分损失:高度形态影响和进展
Roberto Onner Cruz-Tapia1, Ana María Cano-Valdez2, Abelardo Meneses-García3
1Medical, Odontological and Health Science Doctorate Program, Oral and Maxillofacial Pathology Department, Postgraduate School of Dentistry, National Autonomous University of Mexico, Mexico City 04510, Mexico.
交换机/非发酵糖 (SWI/SNF) 复合物的缺陷,特别是SMARCB1和SMARCA4,与激进的鼻腔状细胞癌 (SNSCCs) 有关. 部分丧失SMARCB1与生存率差相关,而SMARCA4的改变影响瘤大小.
科学领域:
- 在瘤学瘤学.
- 分子病理学分子病理学
- 癌症遗传学 癌症遗传学
背景情况:
- 鼻癌是具有不同遗传特征的侵袭性瘤.
- 交换机/糖非发酵 (SWI/SNF) 染色质重塑复合物的改变与各种癌症有关.
- 在高度鼻瘤中,注意到SWI/SNF子单元如SMARCB1/INI1和SMARCA4/BRG1的缺陷.
研究的目的:
- 通过免疫组织化学研究,研究SWI/SNF复合体在鼻腔状细胞癌 (SNSCCs) 中的状态.
- 在SNSCC中将SWI/SNF蛋白表达与组织学特征和患者存活率相关联.
主要方法:
- 对103种鼻癌的分析,重点是高度形态学.
- 对SMARCB1和SMARCA4蛋白质表达的免疫组织化学评估.
- 蛋白质表达模式与瘤行为和患者生存数据的比较.
主要成果:
- 对SMARCB1的马赛克表达在33%的非角质化SNSCC和21.9%的角质化SNSCC中观察到.
- 对SMARCA4的马赛克表达在14.6%的非角质化和12.2%的角质化SNSCC中被确定.
- 分别在9%和4%的病例中发现了SMARCB1和SMARCA4缺陷,影响了瘤大小和进展.
结论:
- 在SNSCC中,SMARCB1的部分损失 (马赛克表达) 与高度恶性瘤有关,并对患者的生存有负面影响.
- 在SNSCC中,SMARCA4马赛克表达与与SMARCA4完整的瘤相比,高度特征和瘤大小增加有关.
- SWI/SNF复合体的改变是预测鼻状状细胞癌的重要生物标志物.
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