改变肠道菌群可以改善宿主新陈代谢,减轻慢性缺氧造成的损害
Zheng Chen1, Yang Liao1, Shatuo Chai1
1Ministry of Agriculture and Rural Affairs Key Laboratory of Animal Nutrition and Forage-Feed of Grazing Yak and Tibetan Sheep in Qinghai-Tibetan Plateau, Key Laboratory of Plateau Grazing Animal Nutrition and Feed Science of Qinghai Province, Yak Engineering Technology Research Center of Qinghai Province, Qinghai Academy of Animal Husbandry and Veterinary Sciences, Qinghai University, Xining 810016, China.
将高海拔适应物种的肠道微生物移植到老鼠身上,减轻了缺氧损伤. 这种方法改善了体重增加,料效率,并降低了肺高血压,提供了一种新的治疗策略.
科学领域:
- 生理学 生理学 生理学
- 微生物学 微生物学
- 高度医学 高度医学
背景情况:
- 缺氧导致食欲下降,生长问题,炎症和肺高血压.
- 肠道功能失调与缺氧相关的健康问题有关.
研究的目的:
- 调查肠道微生物种植是否可以减轻缺氧诱导的损害.
- 评估高海拔适应微生物群对模拟高海拔条件下的生理和代谢参数的影响.
主要方法:
- 从Ochotona curzoniae移植的肠道微生物群进入斯普雷格·道利大鼠.
- 暴露于模拟6000米高度的老鼠30天.
- 分析了平均每日体重增加 (ADG),料转换率 (FCR),平均肺动脉压 (mPAP),肠道菌群和便新陈代谢.
主要成果:
- 与对照组相比,移植组的ADG显著增加,FCR降低.
- 肺动脉平均压力 (mPAP) 在移植组显著下降.
- 多omics分析确定了Lachnospiraceae,Desulfovibrionaceae和氨基酸代谢作为关键因素.
结论:
- 从高海拔适应物种移植肠道微生物群可以有效减轻缺氧引起的损害.
- 这种干预改善了营养代谢,并在缺氧条件下降低了肺高血压.
- 这项研究提出了一种新的治疗方法,用于低氧相关的条件和高海拔适应.
更多相关视频
05:41Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
相关概念视频
Bacterial Flora of the Large Intestine
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
Bioremediation
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Carbon-dioxide Fixation
