牙周炎引起了代谢综合征的视网膜神经退行性影响:一个横截面研究
Hatice Arslan1, Nur Yorgancilar1, Oguz Kose1
1Department of Periodontology, School of Dentistry, Recep Tayyip Erdogan University, Rize 53100, Turkey.
Dentistry journal
|November 26, 2024
概括
牙周炎和代谢综合征 (MetS) 可以导致全身炎症. 结合起来,它们可能会恶化视网膜神经退行,影响视网膜和胸腔厚度.
科学领域:
- 眼科医生 眼科 眼科
- 牙周病学 牙周病学
- 代谢疾病 代谢疾病
背景情况:
- 牙周炎和代谢综合征 (MetS) 是普遍存在的慢性疾病.
- 这两种情况都与全身炎症和氧化应激有关.
- 它们对眼睛结构的综合影响,特别是视网膜和胸膜,仍然不完全理解.
研究的目的:
- 为了研究牙周炎,MetS及其组合的视网膜-胆道性退行性影响.
- 通过光学连贯断层扫描 (OCT) 评估视网膜和胸膜的形态和血管变化.
主要方法:
- 一项涉及92名患者的横截面研究,分为四组:健康,仅患有牙周炎 (PD),仅患有MetS (MetS) 和联合PD-MetS.
- 血清炎症标志物的生物化学分析 (TNF-α,IL-1β/IL-10比率,OSI).
- 对视网膜 (AMT,pRNFLT,GCL+T) 和胸膜 (SFCT) 厚度以及毛细管密度的血管测量.
主要成果:
- 牙周炎和MetS都引起了显著的全身炎症应激 (增加IL-1β/IL-10比率和OSI).
- 在MetS和PD-MetS两组中都观察到 Subfoveal Choroidal Thickness (SFCT) 的显著稀薄.
- 结合PD-MetS组显示显著较薄的周包皮质视网膜神经纤维层厚度 (pRNFLT),而MetS组显示较薄的斑点周包皮质视网膜神经纤维层厚度 (AMT).
结论:
- 仅仅是牙周炎并不会导致视网膜和副膜胆道厚度的统计学上显著变化.
- 牙周炎和MetS的结合可能会加剧视网膜神经退行性影响.
- 需要进一步的研究来阐明将这些系统性疾病与眼部健康联系在一起的机制.
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