提高水凝隐形眼镜的性能,使用友多涂层
Paul Demian1, Daichi Nagaya2, Roeya Refaei3
1Menicon R&D Innovation Centre, Menicon Co., Ltd., Nagoya (Japan), Geneva Branch, 1205 Geneva, Switzerland.
Journal of functional biomaterials
|November 26, 2024
概括
研究人员开发了一种15分钟的浸泡涂层工艺,使得疏水性水凝隐形眼镜具有极高的疏水性和脂质排斥性. 这种表面修改提高了每日一次性隐形眼镜的舒适性和性能,没有细胞毒性.
科学领域:
- 生物材料科学 生物材料科学
- 眼科材料工程 眼科材料工程
- 表面化学 表面化学
背景情况:
- 水凝隐形眼镜广泛用于日常一次性佩戴.
- 它们固有的疏水性会导致不适和性能降低.
- 表面修饰对于改善可湿性和生物相容性至关重要.
研究的目的:
- 开发一种高效,适合行业的方法来提高液凝隐形眼镜的表面水友性.
- 研究用于表面功能化的多巴胺辅助共沉积策略.
- 评估涂层对镜片特性,细胞毒性和抗菌活性的影响.
主要方法:
- 一种浸泡涂层过程,涉及酸,多巴胺和一种酸盐衍生物的共同沉积.
- 利用周期性氧化进行快速高效的表面修饰.
- 引入高分子量分支聚乙烯以促进表面反应.
- 镜片表面性能的表征,包括水友性和脂质排斥性.
- 对细胞毒性和部分抗菌活性对黄金葡萄球菌的评估.
主要成果:
- 在隐形眼镜表面达到极高的水友性和脂质排斥性.
- 涂层过程很快,在15分钟内完成.
- 修改后的透镜保持了它们的内在特性,并没有显示出细胞毒性.
- 已证明对格拉姆阳性细菌 (金黄色葡萄球菌) 的部分抗菌活性.
结论:
- 多巴胺辅助的共同沉积策略提供了一种多功能且高效的方法,用于将疏水性隐形眼镜转化为水友性隐形眼镜.
- 这种表面修改具有显著的潜力,可以提高每日一次性隐形眼镜的舒适性和性能.
- 开发的涂层作为创建先进抗微生物隐形镜片表面的基础.
相关概念视频
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In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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