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含有黄素原药和的酸在骨肉瘤治疗中具有双功能的作用

Mingjie Wang¹, Chunfeng Xu¹, Dong Xu^2,3,4

¹Academic Centre for Dentistry Amsterdam (ACTA), Department of Oral Cell Biology, Vrije Universiteit Amsterdam and University of Amsterdam, 1081 LA Amsterdam, The Netherlands.

Journal of functional biomaterials

|November 26, 2024

概括

这项研究引入了一种结合和在酸上的新生物材料,用于增强癌症治疗和骨再生. 这种新材料显示出协同作用的抗癌效应,并促进骨质生成,为骨癌治疗提供了潜力.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
癌症研究癌症研究

背景情况:

酸用于癌症治疗,但骨再生仍然是一个挑战.
黄素表现出抗癌性质,并促进骨质生成.
开发多功能生物材料对于结合癌症治疗和骨修复至关重要.

研究的目的:

开发一种新的生物材料 (mcur-Se@BioCaP-Ads),在仿生酸盐 (BioCaP) 上结合 (SeO32-) 和黄素 (mcur).
评估新生物材料对骨髓瘤 (OS) 细胞的协同抗癌疗效.
评估生物材料在促进骨组织再生方面的潜力.

主要方法:

将SeO32-离子共同沉到BioCaP中以形成Se@BioCaP.
在Se@BioCaP表面上对修饰的黄素前药物 (mcur) 的吸附 (mcur-Se@BioCaP-Ads).
评估pH响应释放,OS细胞中的体外抗癌活性,以及MC3T3-E1前骨质细胞中的骨质生成潜力.

主要成果:

Se@BioCaP表现出更高的含量和可调节的微/纳米结构.
mcur-Se@BioCaP-Ads证明了Se和mcur的pH响应释放.
在OS细胞中观察到协同作用的抗癌作用,超过单剂疗效,可能通过ROS生产.
在骨质前细胞中发现性酸酶活性增加和结节的形成.

结论:

新的mcur-Se@BioCaP-Ads生物材料显示了对OS细胞有前途的协同抗癌活性.
该材料有效地促进骨质分化,表明骨组织再生的潜力.
这种多功能生物材料具有治疗骨髓瘤和增强骨修复的巨大潜力.

关键词:

这就是ROSOS ROS.生物仿真酸是酸的生物仿真物.库尔库明是一种黄素.骨质发生过程 (osteogenesis)骨质肉瘤是骨质肉瘤的一种疾病.是一种.

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