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内微生物群:从解剖学,分子和临床角度的洞察

Claudia Lombardo¹, Rosanna Fazio¹, Marta Sinagra¹

¹Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.

Journal of personalized medicine

|November 26, 2024

概括

人体内微生物群,瘤内的微生物,影响癌症的发展,进展和治疗反应. 了解这种复杂的微生物群体为改善癌症诊断和预后提供了潜力.

科学领域:

在瘤学瘤学.
微生物学微生物学
癌症研究癌症研究

背景情况:

人体拥有多样化的微生物群落,称为微生物群.
虽然肠道微生物群得到了充分的研究,但有证据表明,不同的微生物群殖民于其他器官,包括瘤.
这些居住在瘤中的微生物被称为"瘤内微生物群".

研究的目的:

审查目前对内微生物群在癌症中的作用的理解.
探索其对癌症发展,进展和治疗疗效的影响.
讨论内微生物群的诊断和预后潜力.

主要方法:

关于内微生物群和癌症的最新研究的文献综述.
对微生物对致癌和转移的贡献的研究分析.
检查调查微生物群对瘤微环境 (TME) 和治疗反应的影响的研究.

主要成果:

内微生物群可以通过DNA损伤,炎症和瘤性途径促进癌症的发病和转移.
微生物显著改变瘤微环境 (TME).
内微生物群的组成和活性会影响抗癌疗法的有效性.

结论:

内微生物群在癌症生物学中起着至关重要的作用.
研究内微生物群为癌症诊断和预后提供了有希望的途径.
向瘤内微生物群可能会改善癌症患者的管理和治疗结果.

关键词:

微生物的解剖学分布.肠道内口微生物群微生物组是一个微生物组.我们的微生物群.

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