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从Trichoderma hamatumb-3中分离的二次代谢物的结构和杀菌活性

Li Huang¹, Qiang Bian², Mengdan Liu³

¹State Key Laboratory of Southwestern Chinese Medicine Resource, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Journal of fungi (Basel, Switzerland)

|November 26, 2024

概括

这项研究从Trichoderma hamatum中分离出新型化合物,显示出显著的杀菌活性. 化合物10表明对病原性真菌有强烈的抑制作用,显示出生物杀虫剂开发的前景.

科学领域:

自然产品化学自然产品化学
菌类学菌类学是指菌类学.
生物技术是生物技术.

背景情况:

特里科德玛哈马图姆是一种已知的生产生物活性二次代谢产物的真菌.
研究真菌代谢物对于发现各种应用的新生物活性化合物至关重要.

研究的目的:

从Trichoderma hamatum b-3中分离和描述二次代谢物.
评估分离化合物的杀菌活性对植物病原菌的作用.
探索这些化合物作为生物杀虫剂的潜力.

主要方法:

使用色谱技术分离化合物.
使用高分辨率电喷射电离质谱法 (HRESIMS) 和核磁共振 (NMR) 谱法阐明结构.
使用NMR,电子循环二元化 (ECD) 计算和莫舍尔法来确定绝对配置.
在体外和体内真菌杀菌活性测定对Fusarium graminearum,Sclerotinia sclerotiorum,Botrytis cinerea和Rhizoctonia solani.进行检测.

主要成果:

分离了两种新的harziane diterpenes和五种新的cyclonerane sesquiterpenes,以及三种已知的化合物.
化合物10 (脱酸) 在体外显示出100%的抑制作用,对抗Sclerotinia sclerotiorum和Botrytis cinerea.
化合物10在体内显示出65.8%的抗 Botrytis cinerea 的有效性.

结论:

该研究成功地确定了T. hamatum的新型和已知的化合物,具有显著的杀菌性质.
化合物10是开发生物杀虫剂的有前途的头,特别是针对 Botrytis cinerea.
这些发现凸显了T. hamatum作为生物控制剂来源的潜力.

关键词:

三角皮肤 (Trichoderma) 是一种三角皮肤.这是一种二二烯 ( diterpene).它具有杀菌活性,具有杀菌活性.这种物质叫做sesquiterpene.

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