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来自远东海星 (Ceramaster patagonicus) 的具有抗氧化活性的新型多基化物

Timofey V Malyarenko^1,2, Viktor M Zakharenko^1,2, Alla A Kicha¹

¹G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.

|November 26, 2024

概括

来自色饼干星的新型类固醇糖化物显示出抗氧化和抗炎性质. 这些化合物,包括新型的类固醇,有效地降低了微质细胞中的炎症标记物.

科学领域:

海洋天然产品化学化学
药理学药理学是指药理学的学科.
有机化学有机化学

背景情况:

深海生物是新型生物活性化合物的丰富来源.
来自海洋无脊椎动物的类固醇糖化物表现出多种生物活性.
色饼干星,Ceramaster patagonicus,是一个独特的海洋天然产品的潜在来源.

研究的目的:

从Ceramaster patagonicus*中分离和表征新的多氧类固醇糖化物.
研究这些孤立化合物的抗炎和抗氧化活性.

主要方法:

使用色谱技术分离化合物.
使用核磁共振 (NMR) 和电喷离子质谱法 (ESIMS) 阐明新化合物的结构.
在体外评估使用脂聚糖 (LPS) 诱导的小鼠微质细胞系 (SIM-A9) 的抗炎活性.
通过测量麦隆迪甲 (MDA) 生产来评估抗氧化活性.

主要成果:

他们分离出了四种新型的多氧化类固醇甘氨酸 (Ceramasterosides A,B,D,E) 和两种已知的化合物.
化合物1,3,和5在LPS诱导的炎症期间显著降低了细胞内氧化 (NO) 的产生.
化合物4在减少细胞外亚酸盐生产方面最有效,所有测试的化合物都降低了甲 (MDA) 产量,表明抗氧化作用.

结论:

从Ceramaster patagonicus*中发现了具有独特的糖化模式的新型类固醇糖化物.
隔离的化合物,特别是Ceramasterosides A,B,D和E,在体外表现出显著的抗炎和抗氧化活性.
这项研究突出了海洋衍生类固醇糖化物作为治疗炎症和氧化压力相关疾病的治疗剂的潜力.

关键词:

这就是Ceramaster patagonicus.在NMR和MS频谱中.抗氧化剂活性抗氧化剂活性聚氧化类固醇的糖化物.海星是什么意思海星是什么意思

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