孕产妇肥胖和儿童尿液代谢的差异
Ellen C Francis1, Kelly J Hunt2, William A Grobman3
1Department of Biostatistics & Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA.
Metabolites
|November 26, 2024
概括
怀孕期间的孕产妇肥胖会改变儿童的尿液代谢物,影响与肠道微生物和激素相关的途径. 这些代谢变化可能为暴露于子宫中肥胖的后代的长期健康影响提供见解.
科学领域:
- 代谢学 代谢学 代谢学
- 发展生物学 发展生物学
- 公共卫生 公共卫生
背景情况:
- 孕产妇的肥胖影响了美国约三分之一的怀孕.
- 怀孕期间的肥胖会对子宫内环境和后代发育产生负面影响.
研究的目的:
- 为了研究暴露和未暴露于母亲肥胖的儿童之间的尿液代谢学上的差异.
- 为了确定潜在的生物标志物和与子宫内暴露于孕产妇肥胖相关的受影响途径.
主要方法:
- 在68名儿童 (4-8岁) 中使用液体染色学-质谱的非向性尿液代谢.
- 暴露于母体肥胖的后代 (母体BMI≥30.0 kg/m2) 和未暴露的后代 (母体BMI18.5-24.9 kg/m2) 之间的代谢物水平的比较.
- 统计分析包括两个样本的t测试和基于儿童的BMI的灵敏度分析.
主要成果:
- 暴露于母亲肥胖症的儿童表现出较低的5-英二醇硫酸盐和7-英二醇硫酸盐水平,以及较高的二次胆酸水平.
- 在暴露于母亲肥胖的后代和超重/肥胖BMI的后代中观察到较低水平的酸衍生物.
- 暴露于孕产妇肥胖与降低脱水氨二硫酸盐 (DHEA-S) 水平有关.
结论:
- 暴露于母亲肥胖的儿童表现出明显的尿液代谢物概况,这表明酸和乙化的微生物代谢发生了变化.
- 一些观察到的代谢差异部分与后代当前的BMI状态有关.
- 尿液代谢学显示出有希望的生物标志物和受孕中暴露于孕产妇肥胖影响的途径的识别.
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