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相关概念视频

Genomics02:02

Genomics

35.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.9K
Operon Model01:23

Operon Model

2
The operon model represents a fundamental mechanism of gene regulation in prokaryotes, enabling coordinated expression of genes involved in related metabolic or functional pathways. Operons consist of structural genes, a promoter, and an operator, with transcription regulated by repressors, activators, and small effector molecules.Structure and Function of OperonsAn operon is a cluster of structural genes transcribed together under the control of a single promoter. The promoter region...
2
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

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Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
28

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相关实验视频

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Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
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使用基因组规模代谢模型整合和分析Omics数据.

Miha Moškon1, Tadeja Režen2

  • 1Faculty of Computer and Information Science, University of Ljubljana, 1000 Ljubljana, Slovenia.

Metabolites
|November 26, 2024
PubMed
概括

基于约束的建模和基因组规模的代谢模型 (GEMs) 通过分析omics数据,为复杂的生物系统提供机械洞察力. 这些计算工具对于理解代谢网络至关重要.

科学领域:

  • 计算生物学 计算生物学
  • 系统生物学 系统生物学
  • 代谢工程是代谢工程.

背景情况:

  • 基因组规模的代谢模型 (GEMs) 整合了多omics数据来表示细胞代谢.
  • 基于约束的建模 (CBM) 分析GEM来预测代谢功能和表型.
  • GEM和CBM提供了对生物系统的机械学理解.

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