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长期COVID-19感染患者的唾液代谢学

Luiz Machado¹, Robson Prudente¹, Estefânia Franco¹

¹Botucatu Medical School, São Paulo State University, Botucatu 18618-970, Brazil.

|November 26, 2024

概括

长期COVID患者在出院60天后的唾液中表现出较低水平的特定代谢物,包括肌酸. 这种减少的肌酸可能与长期COVID患者经历的持续疲劳和身体能力下降有关.

科学领域:

生物化学生物化学
代谢学代谢学代谢学
后COVID条件后COVID条件

背景情况:

长期COVID-19的定义是症状持续超过4周的急性感染后.
长期COVID临床表现的潜在病理生理学仍然不太清楚.
研究代谢变化为长期COVID病理生理学提供了潜在的见解.

研究的目的:

为了评估长期COVID患者的唾液代谢物丰度,医院出院后60天.
确定与长期COVID症状和病理生理学相关的潜在生物标志物.
为了比较长期COVID患者和非COVID-19对照者之间的代谢物概况.

主要方法:

对30名退院后长期COVID患者和7名健康对照进行了唾液代谢分析.
长期COVID患者接受了全面的临床评估,包括螺旋计,6分钟步行测试 (6mWT) 和呼吸问卷.
统计分析确定了两组之间差异表达的代谢物.

主要成果:

与对照人群相比,长期COVID患者的代谢学揭示了19种差异表达的代谢物.
16种代谢物表现出较低的丰度,2种在长期COVID患者中缺席.
在长期的COVID患者中观察到显着较低的卡伦杜化物G甲基,Gly Pro Lys和肌酸水平.

结论:

与健康人相比,长期COVID患者表现出不同的唾液代谢物概况.
减少特定代谢物的丰度,特别是肌酸,可能与长期COVID相关的疲劳和减少的身体能力有关.
唾液代谢学对理解和潜在地诊断长期COVID有希望.

关键词:

在 COVID-19 疫情中,功能能力的功能能力.代谢生物组的代谢生物组在COVID-19后的时间里.

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