PM2.5 暴露作为2型糖尿病中视神经健康的危险因素
Tianyi Yuan1,2, Minna Cheng3, Yingyan Ma1,2
1Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, No. 85/86, Wujin Road, Shanghai 200080, China.
Toxics
|November 26, 2024
概括
长期暴露于细颗粒物 (PM2.5) 与2型糖尿病患者的视觉盘尺寸和比率减少有关,这可能表明视觉神经受损.
科学领域:
- 眼科医生 眼科 眼科
- 环境健康 环境健康
- 糖尿病学 糖尿病学
背景情况:
- 2型糖尿病 (T2DM) 是一个日益严重的全球健康问题.
- 糖尿病与各种眼部并发症有关,包括视神经损伤.
- 颗粒物 (PM2.5) 暴露是心血管和呼吸系统疾病的已知风险因素,新出现的证据将其与神经效应联系起来.
研究的目的:
- 调查T2DM患者长期暴露于细颗粒物 (PM2.5) 和光盘参数之间的关联.
- 评估PM2.5对垂直杯与光盘比率 (vCDR),垂直光盘直径 (vDD) 和垂直光杯直径 (vCD) 的影响.
主要方法:
- 来自上海糖尿病眼病队列研究 (SCODE) (2017-2018) 的65,750名T2DM患者的截面分析.
- 光盘参数从 fundus 图像中进行测量.
- 估计PM2.5暴露使用一个随机森林模型整合卫星和气象数据.
- 使用多变量线性回归模型,对诸如年龄,BMI,血压,葡萄糖水平,糖尿病持续时间和生活方式因素等混因素进行调整.
主要成果:
- 暴露在PM2.5中的10μg/m3的增加与vCDR (-0.008),vDD (-42.547μm) 和vCD (-30.517μm) 的减少显著相关 (p < 0.001).
- 在对其他空气污染物 (O3,NO2) 的敏感性分析和调整后,这些关联仍然很重要.
结论:
- 在T2DM患者中,长期暴露于PM2.5与光盘参数的不良变化相关.
- 这些发现表明PM2.5暴露与视神经缩之间存在潜在联系.
- 鉴于视神经与中枢神经系统的连接,这些结果可能意味着与空气污染相关的更广泛的神经退行性影响.
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