暴露于污染物和疫苗的有效性:一个系统的审查
Carmela Protano1, Federica Valeriani2, Katia Vitale1
1Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Vaccines
|November 26, 2024
概括
环境污染物可能会降低疫苗抗体反应. 污染控制可以提高疫苗的有效性,但需要更多的研究来证实这些发现并设定暴露限值.
科学领域:
- 环境科学 环境科学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 人类活动将污染物释放到空气,水和土壤中.
- 暴露于环境污染物是不可避免的.
- 了解污染物对疫苗免疫力的影响至关重要.
研究的目的:
- 审查关于环境污染物对疫苗诱导的抗体产生影响的研究.
- 评估污染物暴露与疫苗免疫反应之间的关系.
主要方法:
- 按照PRISMA指南进行系统审查.
- 包括意大利语和英语的观察性,半实验性和实验性研究.
- 分析了42项研究,研究了污染物对疫苗抗体水平的影响.
主要成果:
- 大多数研究表明,污染物暴露与抗体产生减少之间存在相关性.
- perfluorinated 化合物是经常研究的污染物.
- 检查了疫苗对包括COVID-19在内的各种抗原的反应.
结论:
- 污染控制可以提高疫苗接种活动的有效性.
- 研究异质性阻止了元分析.
- 需要进一步的研究来证实这些发现,并确定污染物暴露限值.
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