除了抑制之外:周围T细胞对免疫接种的反应在炎症性肠病患者中,这些患者正在接受抗瘤缩因子治疗
Martin Qui1, Ennaliza Salazar2
1Duke-NUS Medical School, Singapore 169857, Singapore.
Vaccines
|November 26, 2024
概括
瘤坏死因子 (TNF) 抑制剂有助于炎症性肠病 (IBD) 患者实现缓解,但可能会影响疫苗反应. 本综述检查了抗TNF治疗IBD患者的T细胞免疫力和COVID-19疫苗的有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 炎症性肠病 (IBD) 是通过全身免疫调节药物进行管理的,特别是针对瘤死因子 (TNF) 的生物药物.
- 抗TNF疗法对IBD缓解有效,但与感染风险增加和疫苗免疫性降低有关.
- 对于接受抗TNF治疗的IBD患者适应性T细胞反应的了解有限.
研究的目的:
- 对接受抗TNF治疗的IBD患者疫苗诱导的T细胞反应的新发现进行审查.
- 评估最近的研究如何完善我们对免疫调节疗法对免疫和保护的影响的理解.
- 突出这一患者队伍中细胞和幽默免疫的综合评估的必要性.
主要方法:
- 对最近关于抗TNF疗法,IBD和疫苗反应 (包括COVID-19疫苗) 的研究的文献综述.
- 在抗TNF治疗的背景下对适应性T细胞反应的分析.
- 综合发现,评估对免疫和保护的影响.
主要成果:
- 抗TNF疗法影响宿主基本免疫反应,影响疫苗的疗效.
- COVID-19疫苗研究为免疫调节疗法对T细胞免疫的影响提供了新的见解.
- 对抗TNF治疗IBD患者T细胞反应的现有数据仍然有限,需要进一步调查.
结论:
- 对细胞和幽默免疫的全面评估对于了解抗TNF治疗的IBD患者的疫苗诱导反应至关重要.
- 需要进一步的研究,以充分阐明抗TNF治疗,T细胞功能和IBD疫苗有效性之间的复杂相互作用.
- 新的发现挑战并改进了当前对免疫调节疗法对免疫和保护的影响的看法.
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