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Updated: Jul 10, 2026

A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators
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A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators

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针对不同矩阵中的大量肉毒神经毒素血清和亚型的国际能力测试

Christine Rasetti-Escargueil1, Michel Robert Popoff1, Bettina Kampa2

  • 1Unité des Toxines Bactériennes, UMR CNRS 6047, Inserm U1306, Université Paris-Cité, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France.

Toxins
|November 26, 2024
PubMed
概括

这项研究评估了检测肉毒神经毒素 (BoNTs) 的实验室间能力测试. 结果突出了有效的方法和培训和参考材料的需要,以提高BoNT检测准确度.

关键词:
肉毒神经毒素 (BoNTs) 是一种神经毒素.肉毒主义 (botulism) 是一种疾病.诊断 诊断 诊断 诊断 诊断 诊断能力测试 能力测试 能力测试

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相关概念视频

Botulism01:22

Botulism

Botulism is a life-threatening neuroparalytic condition caused by botulinum neurotoxin, which is produced by the bacterium Clostridium botulinum, a Gram-positive, spore-forming, obligate anaerobe.In adults, the toxin enters the body in different ways: in foodborne botulism, the preformed toxin is absorbed in the intestine. In wound botulism, spores grow in injured tissue and release the toxin into the blood. Infant botulism differs mechanistically from adult forms. In infants, botulism commonly...