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Updated: Jul 21, 2026

Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation
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Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation

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通过单细胞分析,探索使用小鼠作为研究老化和阿尔茨海默病中微质细胞的替代模型的可行性

Rong He1, Qiang Zhang1, Limei Wang1

  • 1Laboratory Animal Department, Kunming Medical University, Kunming, Yunnan, China.

PloS one
|November 26, 2024
PubMed
概括

鼠标Apoe和Cx3cr1对研究阿尔茨海默氏症 (AD) 和人类衰老有希望. 然而,目前的AD小鼠模型在完全复制人类AD和衰老基因表达方面存在局限性,这凸显了研究中需要人类样本的需求.

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相关概念视频

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...