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Updated: Jun 6, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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对依赖折叠的灵活性与人工智能蛋白质结构预测之间的关系进行系统分析

Neshatul Haque1, Jessica B Wagenknecht1, Brian D Ratnasinghe1

  • 1Computational Structural Genomics Unit, Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, United States of America.

PloS one
|November 26, 2024
PubMed
概括

像AlphaFold v2这样的人工智能 (AI) 模型可以准确地预测单个蛋白质结构. 然而,许多蛋白质表现出灵活性,其中一些折叠显示出对生物过程至关重要的显著构造变异.

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