用于药物输送载体的甘油聚合物外合成和表征多离子复合菌根
Tomoki Ando1, Thi Ngan Vu1, Tomoya Nishimura1
1Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan.
Langmuir : the ACS journal of surfaces and colloids
|November 26, 2024
概括
研究人员从水友双块共聚合物中合成了聚离子复合物 (PIC) 聚合物. 聚合物块长度的比率显著影响PIC聚合物的稳定性和形态学,有些聚合物形成稳定的微粒,而另一些聚合物随着时间的推移而聚合.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 超分子化学 超分子化学
背景情况:
- 水性双块共聚合物为自组装提供了多功能构建块.
- 控制聚合物架构对于设计功能性材料至关重要.
- 多离子复合体 (PIC) 的形成依赖于相反电荷的聚合物之间的静电相互作用.
研究的目的:
- 通过RAFT聚合合成合成新型水友性双块共聚合物.
- 为了研究聚离子复合物 (PIC) 聚合物的形成和特征.
- 为了确定聚合物块长度比对PIC聚合物形态和稳定性的影响.
主要方法:
- 可逆添加碎片化链转移 (RAFT) 激进聚合用于双块共聚合物合成.
- 混合基于PGEMA的阴离子和阴离子双块共聚合物,形成PIC聚合物.
- 使用动态光散射 (水力动力半径) 和泽塔电位测量,对PIC聚合物的表征.
- 评估随着时间的推移和不同NaCl度的合体稳定性.
主要成果:
- 合成的基于PGEMA的阳离子 (PGEMA-b-PTMA) 和阳离子 (PGEMA-b-PSSA) 双块共聚合物.
- 形成的PIC聚合物 (例如G20A100/G20S80和G100A98/G100S78) 的水力动力半径分别为77.4nm和26.2nm.
- 观察到G20A100/G20S80 PIC菌根的时间依赖聚合,与稳定,球形G100A98/G100S78 PIC菌根形成鲜明对比.
- 由于电荷选,PIC聚合物在0.8M NaCl以上被证明是分离的.
结论:
- 水友性块之间的聚合率的程度决定了PIC聚合物的形态和体稳定性.
- 通过仔细选择共聚合物块长度,可以实现稳定,球形的PIC微粒.
- PIC聚合物的稳定性对离子强度敏感,在高度盐中发生解离.
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