评估微生物角质炎中医疗疗失败:风险因素和管理替代方案
David Lamas-Francis1,2, Daniel Navarro3, Raquel Mansilla4
1Department of Ophthalmology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain.
Ocular immunology and inflammation
|November 26, 2024
概括
高龄,深层角膜透和先前的类固醇使用是微生物角质炎 (MK) 治疗失败的关键风险因素. 识别这些因素对于有效的管理和手术干预决策至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
背景情况:
- 微生物角膜炎 (MK) 是视力丧失的重要原因之一.
- 了解治疗结果和失败的风险因素对于患者管理至关重要.
研究的目的:
- 描述感染性角膜炎的治疗方法.
- 确定治疗失败的风险因素,包括长期感染,治疗修改和手术干预需求.
主要方法:
- 追溯的病例系列培养证明的微生物角质炎.
- 包括2010年至2020年期间在西班牙加利西亚9家医院接受治疗的654名患者.
主要成果:
- 长期感染与晚年,深层透,角膜稀薄和大表皮缺陷有关.
- 治疗修改发生在31.2%的病例中,通常是由于耐药性或临床恶化.
- 在21.7%的病例中,需要进行外科手术,其中的风险因素包括先前的角质塑形手术,疹性角质炎,类固醇使用和大型上皮缺陷.
结论:
- 在MK的治疗失败受到系统性 (例如,晚年) 和眼部因素 (例如,大额外皮质缺陷,多微生物感染,植物物质接触,先前使用类固醇) 的影响.
- 识别这些危险因素有助于指导实证治疗和管理需要重症监护或手术的耐火性.
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