风湿性关节炎标准化死亡率的吸烟相关偏差:一个建模研究
1Verier Outcomes Research, USA.
Seminars in arthritis and rheumatism
|November 26, 2024
概括
由于RA患者的吸烟率较高,风湿性关节炎的标准化死亡率 (SMR) 可能会被膨胀. 即使是吸烟率的小幅增加也会扭曲SMR,这表明1.0的基准对RA死亡率可能过于严格.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 类风湿性关节炎 (RA) 的标准化死亡率 (SMR) 通常与一般人群的年龄和性别相匹配.
- 然而,在RA患者群体中吸烟率较高可能会导致SMR计算中的偏差.
- 这项研究调查了吸烟对RA死亡率SMR的影响.
研究的目的:
- 估计在类风湿性关节炎 (RA) 队列中增加吸烟患病率对标准化死亡率 (SMR) 的影响.
- 为了确定当前的SMR基准是否适当,考虑到吸烟对RA群体的影响.
主要方法:
- 利用美国国家健康访谈调查数据 (1999-2004) 创建假设的RA队列,有不同的吸烟率.
- 将具有更高吸烟率的模拟RA队列与代表一般人口的参考队列进行了比较.
- 使用2000个重复样本计算了10年和15年的SMR.
主要成果:
- 一个假设的RA队列,吸烟相对风险为2.0,中位数SMR为1.23 (10年) 和1.17 (15年).
- 在吸烟的相对风险为1.25时,中位数SMR为1.07 (10年) 和1.04 (15年).
- 吸烟强度的差异对SMRs产生了轻微的影响.
结论:
- 风湿性关节炎 (RA) 的SMR可能被高估,因为与普通人群相比,吸烟的患病率更高.
- 对于RA来说,1.0的基准SMR可能过于严格,因为它意味着相同的死亡结果.
- 对吸烟的调整对于准确的RA死亡率评估至关重要.
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