模拟消化和肠道微生物群发酵Lactarius hatsudake Tanaka中的多糖化合物
Qiao Yang1, Songlin Chang1, Yiming Tian1
1Hunan Key Laboratory of Forestry Edible Sources Safety and Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan 410004, PR China.
Food chemistry
|November 26, 2024
概括
乳的 hatsudake 多糖 (LHP) 不被消化,而是被肠道微生物分解成脂肪酸. LHP促进有益的肠道细菌,增强氨基酸和脂质代谢,改善健康.
科学领域:
- 菌类学 菌类学是指菌类学.
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- (Lactarius hatsudake Tanaka) 是一种可食用的,因味道和健康益处而受到重视.
- 来自L. hatsudake (LHP) 的多糖体表现出生物活性,但它们的消化命运尚不清楚.
- 了解LHP消化对于其在功能性食品中的应用至关重要.
研究的目的:
- 为了研究LHP的体外消化和肠道发酵.
- 评估LHP对肠道微生物群组成和功能的影响.
- 用小鼠模型评估LHP对宿主代谢的影响.
主要方法:
- 在体外模拟的消化和便发酵模型.
- 对LHP降解产品,分子量和碳水化合物含量的分析.
- 16S rRNA基因测序用于肠道微生物群分析.
- 在小鼠模型中分析血清代谢物.
主要成果:
- 虽然LHP抵抗了模拟的消化,但被肠道微生物降解成脂肪酸.
- 微生物降解导致LHP分子量,碳水化合物含量和pH降低.
- 这种LHP显著促进了有益细菌 (例如,Faecalibacterium,Bifidobacterium) 和抑制了病原体 (例如,Escherichia).
- 血清分析显示LHP调节氨基酸和脂质代谢.
结论:
- 主要由肠道微生物群代谢,产生有益的脂肪酸.
- LHP作为一种益生菌,调节肠道微生物群的组成和功能.
- 通过改善肠道和代谢调节,LHP显示出提高宿主健康的潜力.
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