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塞拉斯特斯 (Celastrus orbiculatus Thunb.) 是一个的动物. 提取物抑制了巨细胞的炎症代谢适应,并通过调节PKM2调节极化来调节极化

Xiaoze Zhang¹, Junsong Wen¹, Ziwei Pan¹

¹Chinese Integrative Medicine Oncology Depatrment, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230000, China.

International immunopharmacology

|November 26, 2024

概括

Celastrus orbiculatus提取物 (COE) 通过调节巨细胞炎症来逆转癌前胃癌病变. COE减少M1极化和炎症因素,可能通过抑制酸激酶M2 (PKM2) 表达.

科学领域:

免疫学免疫学免疫学
胃肠病学胃肠病学
药理学药理学是指药理学的学科.

背景情况:

胃癌的癌前病变 (PLGC) 对胃癌 (GC) 的预防至关重要.
胃粘膜炎症是PLGC发展的先决条件.
巨细胞在启动炎症方面发挥着关键作用.

研究的目的:

为了研究塞拉斯特鲁斯或比库拉图斯 (Celastrus orbiculatus Thunb.b.) 的影响. 提取物 (COE) 关于巨细胞的代谢适应和两极化.
了解COE如何调节炎症反应以逆转PLGC.
探索酸盐激酶M2 (PKM2) 在COE治疗机制中的作用.

主要方法:

使用复合建模方法建立PLGC鼠标模型.
评估COE对巨细胞极化标记物的影响 (M1/M2).
在胃粘膜和RAW264.7巨细胞中测量炎症因素.
对酸盐激酶M2 (PKM2) 表达的分析.

主要成果:

COE显著降低了M1巨细胞极化标志物.
COE增加了M2巨细胞极化标记物.
COE降低了胃粘膜和巨细胞中的炎症因子水平.
而COE则抑制了PKM2.2的表达.

结论:

COE显示出抗炎作用,有利于逆转PLGC.
COE调节了巨细胞的两极分化,从一种促炎性 (M1) 变为一种抗炎性 (M2) 现型.
在PLGC中COE的治疗作用可能涉及PKM2表达的调节,从而调节炎症反应.

关键词:

塞拉斯特斯 (Celastrus orbiculatus Thunb.) 是一个的动物. 提取物提取物胃类有机物,PKM2 炎症性代谢适应炎症性代谢适应巨细胞的两极分化胃癌的癌前病变胃癌的癌前病变

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