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马和小马中的黑色皮质素2受体的分布和序列分析

Christina M Cash¹, Melody A de Laat¹

¹School of Biology and Environmental Science, Queensland University of Technology, Brisbane, Queensland, Australia.

Domestic animal endocrinology

|November 26, 2024

概括

黑色皮质素2受体 (MC2R) 基因在马类上腺和垂体腺体中表达,但不在脂肪或皮肤中表达. 没有发现MC2R编码区域的重大遗传变异在马体下垂体帕斯中间功能障碍 (PPID).

科学领域:

兽医医学兽医医学兽医医学
内分泌学在内分泌学.
遗传学是一个遗传学.

背景情况:

黑色皮质素2受体 (MC2R) 在马类垂体中介部分功能障碍 (PPID) 中至关重要,因为它作为ACTH结合部位的作用.
升高的ACTH水平是PPID的特征,但对马类MC2R的了解仍然很差.

研究的目的:

为了研究健康马的PPID相关组织中的MC2RmRNA表达.
分析马匹MC2R基因序列,以检测与马匹和小马的PPID相关的变异.

主要方法:

在上腺,垂体,脂肪和皮肤组织中分析MC2RmRNA表达.
杂交基因捕获和下一代测序马类MC2R编码区域 (前子).

主要成果:

在马上上腺和垂体组织中证实了MC2R基因表达.
在马的脂肪或皮肤组织中没有检测到MC2R表达.
在所有研究的个体和参考基因组中,在MC2R编码区域观察到100%的对对一致性,表明没有与PPID相关的重大遗传变异.

结论:

MC2R基因表达在关键组织中,与其他哺乳动物相一致,与马类PPID相关.
在患有PPID的马中,没有发现MC2R编码区域的显著遗传变异,这表明可能涉及其他因素.
建议进一步研究MC2R组织分布,PPID病例中的功能以及潜在的内在或未识别的外在变体.

关键词:

这就是ACTHTH ACTH.马类动物马类动物遗传学是一个遗传学.在MC2R中,M2R是M2R.下垂体中介部分的功能障碍.

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