具有双重单亲遗传的Veneridae的比较线粒基因组分析和字系学
Tao Xu1, Chuandong He1, Xiao Han1
1Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, People's Republic of China.
Open biology
|November 26, 2024
概括
双重单亲遗传 (DUI),一种不寻常的mtDNA传播,在七种Veneridae鱼物种中得到证实. 它们的线粒体基因组在未指定的区域中揭示了独特的结构,表明了功能角色和进化见解.
科学领域:
- 线粒体遗传学 线粒体遗传学
- 进化生物学 进化生物学
- 双管子基因组学 双管子基因组学
背景情况:
- 双单亲遗传 (DUI) 是一种罕见的mtDNA遗传系统,其中卵子 (F型) 和精子 (M型) 传递不同的线粒体系.
- 虽然在双动物中已知DUI,但其在Veneridae家族中的流行,功能和进化影响在很大程度上仍未被探索.
- 之前的研究主要记录了海洋和淡水中的DUI,在了解其在其他两动物家族的分布方面存在差距.
研究的目的:
- 为了研究双重单亲遗传 (DUI) 在Veneridae家族中的分布和特征.
- 通过检查线粒体基因组结构,特别是未分配区域 (URs) 来分析DUI的分子进化影响.
- 为了重建DUI携带的Veneridae物种的家族遗传框架.
主要方法:
- 研究了来自Veneridae家族的17个物种.
- 对疑似表现出DUI的物种的线粒体基因组进行了比较.
- 在研究的Veneridae物种之间重建了家族遗传关系.
- 分析了线粒体基因组的未分配区域 (UR),用于重复序列和二次结构形成.
主要成果:
- 通过识别男性生殖腺和添加肌肉中的性别相关的线粒体基因组,证实了七种Veneridae物种中DUI的存在.
- 发现DUI Veneridae物种中44个UR中的13个含有重复序列,其中9个被确定为长期未分配区域 (LUR).
- 发现LURs可以形成次要结构,并与海和哺乳动物控制区域的功能元素共享序列相似性.
- F/M 种系学揭示了 DUI 雌性动物中特定于分类和特定于性别的模式,包括 * Gafrarium dispar * 中男性化的证据.
结论:
- 双重单亲遗传 (DUI) 在科 (Veneridae) 家族中比以前认为的更为普遍.
- 在DUI有性线粒体基因组中,未分配区域 (UR) 与其他种群中的调节元素具有结构和潜在的功能相似性.
- 这些发现为双动物中DUI的分子进化和功能意义提供了关键的见解,突出了潜在的性别特异性进化轨迹.
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